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Protocol example
3 Tesla MRI
info@biosightllc.com
Target cumulative duration = 40 min (current duration approximately 40 min)
Volume
Slice
T1-weighted MPRAGE
Field-of-view = 180 x 256 x 150 mm
Slices = 150
Readout: 3D turbo gradient echo
TR / TE = 8.1 / 3.75 ms
Spatial resolution = 1 x 1 x 1 mm
Duration = 4 min 32 sec
Relevance: Tissue volume, registration, pathology identification, blood-brain barrier permeability (post-Gd)
T2-weighted
Field-of-view = 183 x 230 x 119 mm
Slices = 24
Readout: 2D turbo spin echo (DRIVE)
TR / TE = 3000 / 80 ms
Spatial resolution = 0.36 x 0.45 x 4 mm
Duration = 1 min 48 sec
Relevance: White matter lesions, CSF flow disturbance, subcortical infarcts
T2-weighted FLAIR (Axial)
Field-of-view = 184 x 230 x 134 mm
Slices = 27
Readout: 2D turbo inversion recovery
TR / TE = 11000 / 120 ms
Spatial resolution = 0.46 x 0.57 x 4 mm
Duration = 1 min 21 sec
Relevance: White matter lesions, infarcts
T2-weighted FLAIR (Coronal)
Field-of-view = 161 x 199 x 200 mm
Slices = 40
Readout: 2D turbo inversion recovery
TR / TE = 11000 / 120 ms
Spatial resolution = 0.46 x 0.57 x 4 mm
Duration = 1 min 21 sec
Relevance: White matter lesions, infarcts (confirmation in second plane)
Susceptibility weighted (T2*)
Field-of-view = 183 x 230 x 120 mm
Slices = 120
Readout: 3D gradient echo
TR / TE = 1000 / 80 ms
Spatial resolution = 0.5 x 0.5 x 1 mm
Duration = 2 min 30 sec
Relevance: Microbleeds, venous architecture, glymphatic flow planning
Diffusion weighted
Field-of-view = 230 x 230 x 129 mm
Slices = 26
Readout: 2D spin echo EPI (b=0 and 1000 s/mm2)
TR / TE = 2923.9 / 83.2 ms
Spatial resolution = 1.8 x 1.8 x 4 mm
Duration = 35.1 sec
Relevance: Acute infarct, encephalopathy, restricted diffusion (apparent diffusion, fractional anisotropy)
Head MR Angiography
Field-of-view = 200 x 200 x 84 mm
Slices = 120
Readout: 3D gradient echo
TR / TE = 23 / 3.45 ms
Spatial resolution = 0.39 x 0.39 x 1.4 mm
Duration = 4 min 7 sec
Relevance: Intracranial vasculopathy
Neck MR Angiography
Field-of-view = 200 x 200 x 363 mm (3 stacks)
Slices = 180
Readout: 2D gradient echo
TR / TE = 15.7 / 3.2 ms
Spatial resolution = 0.39 x 0.39 x 3 mm
Duration = 10 min 43 sec
Relevance: Cervical vasculopathy
Arterial spin labeling
Field-of-view = 240 x 240 x 119 mm
Slices = 17
Readout: 2D Gradient echo EPI (factor=33)
TR / TE = 4100 / 15.6 ms
Spatial resolution = 3.5 x 3.5 x 7 mm
Labeling = Pseudocontinuous
PLD / Label duration = 1800 / 1600 ms
Averages = 30
Duration = 4 min 26 sec
Relevance: Cerebral perfusion (ml/100g/min), choroid plexus perfusion, arterio-venous shunting
Diffusion tensor imaging
Field-of-view = 230 x 230 x 130 mm
Slices = 65
Readout: 2D spin echo EPI (32 directions; b=1000 s/mm2)
TR / TE = 3000 / 60 ms
Spatial resolution = 2 x 2 x 2 mm
Duration = 6 min
Relevance: White matter architecture, tractography (structural connectivity), glymphatic flow
Cervical lymph nodes
Field-of-view = 350 x 250 x 446 mm
Slices = 50
Readout: 2D diffusion weighted inversion recovery
TR / TE = 9341 / 68.7 ms
Spatial resolution = 0.78 x 0.56 x 5 mm
Duration = 2 min 58 sec
Relevance: Cervical lymph node count and localization
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